Zinc transporter 8 haploinsufficiency protects against beta cell dysfunction in type 1 diabetes by increasing mitochondrial respiration

• Main Authors: Yong Kyung Kim (Author), Jay A. Walters (Author), Nicole D. Moss (Author), Kristen L. Wells (Author), Ryan Sheridan (Author), Jose G. Miranda (Author), Richard K.P. Benninger (Author), Laura L. Pyle (Author), Richard M. O'Brien (Author), Lori Sussel (Author), Howard W. Davidson (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Zinc transporter 8 (ZnT8) is a major humoral target in human type 1 diabetes (T1D). Polymorphic variants of Slc30A8, which encodes ZnT8, are also associated with protection from type 2 diabetes (T2D). The current study examined whether ZnT8 might play a role beyond simply being a target o...