A regulated NMD mouse model supports NMD inhibition as a viable therapeutic option to treat genetic diseases

A regulated NMD mouse model supports NMD inhibition as a viable therapeutic option to treat genetic diseases

Nonsense-mediated mRNA decay (NMD) targets mRNAs that contain a premature termination codon (PTC) for degradation, preventing their translation. By altering the expression of PTC-containing mRNAs, NMD modulates the inheritance pattern and severity of genetic diseases. NMD also limits the efficiency...

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Bibliographic Details
Main Authors: Josh Echols (Author), Amna Siddiqui (Author), Yanying Dai (Author), Viktoria Havasi (Author), Richard Sun (Author), Aneta Kaczmarczyk (Author), Kim M. Keeling (Author)
Format: Book
Published: The Company of Biologists, 2020-08-01T00:00:00Z.
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