Interferon Regulatory Factor 8 Expressed in Microglia Contributes to Tactile Allodynia Induced by Repeated Cold Stress in Rodents

Interferon Regulatory Factor 8 Expressed in Microglia Contributes to Tactile Allodynia Induced by Repeated Cold Stress in Rodents

Abstract.: We investigated the role of interferon regulatory factor 8 (IRF8) in a model of chronic pain in which repeated cold stress (RCS) exposure produces tactile allodynia. RCS exposure produced a decrease in paw withdrawal threshold (PWT) to mechanical stimulation. Spinal microglia of RCS-expos...

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Main Authors: Takanori Akagi (Author), Yuta Matsumura (Author), Masaya Yasui (Author), Emiko Minami (Author), Hidemasa Inoue (Author), Takahiro Masuda (Author), Hidetoshi Tozaki-Saitoh (Author), Tomohiko Tamura (Author), Kazue Mizumura (Author), Makoto Tsuda (Author), Hiroshi Kiyama (Author), Kazuhide Inoue (Author)
Format: Book
Published: Elsevier, 2014-01-01T00:00:00Z.
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