Modulation of the high concentration viscosity of IgG1 antibodies using clinically validated Fc mutations

• Main Authors: Joel Heisler (Author), Daniel Kovner (Author), Saeed Izadi (Author), Jonathan Zarzar (Author), Paul J. Carter (Author)
• 格式: 圖書
• 出版: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

The self-association of therapeutic antibodies can result in elevated viscosity and create problems in manufacturing and formulation, as well as limit delivery by subcutaneous injection. The high concentration viscosity of some antibodies has been reduced by variable domain mutations or by the addit...