Evaluation of Selected CYP51A1 Polymorphisms in View of Interactions with Substrate and Redox Partner

• Hlavní autoři: Tadeja Režen (Autor), Iza Ogris (Autor), Marko Sever (Autor), Franci Merzel (Autor), Simona Golic Grdadolnik (Autor), Damjana Rozman (Autor)
• Médium: Kniha
• Vydáno: Frontiers Media S.A., 2017-06-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Cholesterol is essential for development, growth, and maintenance of organisms. Mutations in cholesterol biosynthetic genes are embryonic lethal and few polymorphisms have been so far associated with pathologies in humans. Previous analyses show that lanosterol 14α-demethylase (CYP51A1) from the lat...