Quantitative high-throughput screen identifies inhibitors of the Schistosoma mansoni redox cascade.

• Main Authors: Anton Simeonov (Author), Ajit Jadhav (Author), Ahmed A Sayed (Author), Yuhong Wang (Author), Michael E Nelson (Author), Craig J Thomas (Author), James Inglese (Author), David L Williams (Author), Christopher P Austin (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2008-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Schistosomiasis is a tropical disease associated with high morbidity and mortality, currently affecting over 200 million people worldwide. Praziquantel is the only drug used to treat the disease, and with its increased use the probability of developing drug resistance has grown significantly. The Sc...