Design, synthesis, and molecular docking studies of novel pomalidomide-based PROTACs as potential anti-cancer agents targeting EGFRWT and EGFRT790M
A new class of EGFR PROTACs based on pomalidomide was developed, synthesised, and tested for their cytotoxic activity against a panel of human cancer cells. Compounds 15-21 were showed to be more effective against the four tested cell lines than erlotinib. In particular, compound 16 was found to be...
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| Autores principales: | , , , |
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| Formato: | Libro |
| Publicado: |
Taylor & Francis Group,
2022-12-01T00:00:00Z.
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| Acceso en línea: | Connect to this object online. |
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Internet
Connect to this object online.3rd Floor Main Library
| Número de Clasificación: |
A1234.567 |
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| Copia 1 | Disponible |