Use of modeling and simulation to predict the influence of triazole antifungal agents on the pharmacokinetics of zanubrutinib and acalabrutinib

Background: Bruton's tyrosine kinase (BTK) inhibitors are commonly used in the targeted therapy of B-cell malignancies. It is reported that myelosuppression and fungal infections might occur during antitumor therapy of BTK inhibitors, therefore a combination therapy with triazole antifungals is...

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Main Authors: Lu Chen (Author), Chao Li (Author), Hao Bai (Author), Lixian Li (Author), Wanyi Chen (Author)
Format: Book
Published: Frontiers Media S.A., 2022-10-01T00:00:00Z.
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