Rapamycin maintains the primordial follicle pool and protects ovarian reserve against cyclophosphamide-induced damage

• Main Authors: Xiuying CHEN (Author), Zhijing TANG (Author), Haiyun GUAN (Author), Hexia XIA (Author), Chao GU (Author), Yan XU (Author), Bin LI (Author), Wei ZHANG (Author)
• Format: Book
• Published: The Society for Reproduction and Development, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Any abnormal activation of primordial follicles and subsequent depletion can irreversibly diminish the ovarian reserve, which is one of the major chemotherapy-induced adverse effects in young patients with cancer. Herein, we investigated the effects of rapamycin on the activation and development of...