Intranuclear inclusions in hepatocellular carcinoma contain autophagy‐associated proteins and correlate with prolonged survival

• Main Authors: Suzan Schwertheim (Author), Daniela Westerwick (Author), Holger Jastrow (Author), Sarah Theurer (Author), Christoph M Schaefer (Author), Julia Kälsch (Author), Dorothe Möllmann (Author), Martin Schlattjan (Author), Heiner Wedemeyer (Author), Kurt Werner Schmid (Author), Hideo A Baba (Author)
• Format: Book
• Published: Wiley, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract For decades, intranuclear inclusions in many normal and neoplastic cells have been considered to be mere invaginations of cytoplasm into the nucleus without any notable function or influence on disease. We investigated such inclusions in 75 specimens of hepatocellular carcinoma (HCC). In th...