Lipid and Peptide-Oligonucleotide Conjugates for Therapeutic Purposes: From Simple Hybrids to Complex Multifunctional Assemblies

• Hlavní autoři: Carme Fàbrega (Autor), Anna Aviñó (Autor), Natalia Navarro (Autor), Andreia F. Jorge (Autor), Santiago Grijalvo (Autor), Ramon Eritja (Autor)
• Médium: Kniha
• Vydáno: MDPI AG, 2023-01-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Antisense and small interfering RNA (siRNA) oligonucleotides have been recognized as powerful therapeutic compounds for targeting mRNAs and inducing their degradation. However, a major obstacle is that unmodified oligonucleotides are not readily taken up into tissues and are susceptible to degradati...