Re-evaluation of Adrenocorticotropic Hormone and Melanocyte Stimulating Hormone Activation of GPR139 in Vitro

• Hoofdauteurs: Diane Nepomuceno (Auteur), Chester Kuei (Auteur), Curt Dvorak (Auteur), Timothy Lovenberg (Auteur), Changlu Liu (Auteur), Pascal Bonaventure (Auteur)
• Formaat: Boek
• Gepubliceerd in: Frontiers Media S.A., 2018-03-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

It is now well established that GPR139, a G-protein coupled receptor exclusively expressed in the brain and pituitary, is activated by the essential amino acids L-tryptophan (L-Trp) and L-phenylalanine (L-Phe) via Gαq-coupling. The in vitro affinity and potency values of L-Trp and L-Phe are within t...