Identification and Enzymatic Activity Evaluation of a Novel CYP2C9 Allelic Variant Discovered in a Patient

• Main Authors: Xiao-Yang Zhou (Author), Xiang-Ran Lu (Author), Ying-Hui Li (Author), Ya-Qing Ma (Author), Shi-Wen Zhao (Author), Fang Wang (Author), Ren-Ai Xu (Author), Guo-Xin Hu (Author), Jian-Ping Cai (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Warfarin is a widely prescribed anticoagulant but the doses required to attain the optimum therapeutic effect exhibit dramatic inter-individual variability. Pharmacogenomics-guided warfarin dosing has been recommended to improve safety and effectiveness. We analyzed the cytochrome P450 2C9 (CYP2C9)...