Identification and Enzymatic Activity Evaluation of a Novel CYP2C9 Allelic Variant Discovered in a Patient

• Główni autorzy: Xiao-Yang Zhou (Autor), Xiang-Ran Lu (Autor), Ying-Hui Li (Autor), Ya-Qing Ma (Autor), Shi-Wen Zhao (Autor), Fang Wang (Autor), Ren-Ai Xu (Autor), Guo-Xin Hu (Autor), Jian-Ping Cai (Autor)
• Format: Książka
• Wydane: Frontiers Media S.A., 2021-02-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Warfarin is a widely prescribed anticoagulant but the doses required to attain the optimum therapeutic effect exhibit dramatic inter-individual variability. Pharmacogenomics-guided warfarin dosing has been recommended to improve safety and effectiveness. We analyzed the cytochrome P450 2C9 (CYP2C9)...