Sirtuin-6 Preserves R-spondin-1 Expression and increases Resistance of intestinal Epithelium to injury in Mice

• Main Authors: Fangyi Liu (Author), Heng-Fu Bu (Author), Hua Geng (Author), Isabelle G. De Plaen (Author), Chao Gao (Author), Peng Wang (Author), Xiao Wang (Author), Jacob A. Kurowski (Author), Hong Yang (Author), Jiaming Qian (Author), Xiao-Di Tan (Author)
• Format: Book
• Published: BMC, 2017-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Sirtuin-6 (Sirt6) is a critical epigenetic regulator, but its function in the gut is unknown. Here, we studied the role of intestinal epithelial Sirt6 in colitis-associated intestinal epithelial injury. We found that Sirt6, which is predominantly expressed in epithelial cells in intestinal...