Inhibition of NNMT enhances drug sensitivity in lung cancer cells through mediation of autophagy

• Main Authors: Jian Wang (Author), Ming Zhang (Author), Xin You (Author), Yang Xu (Author), Congcong Zhang (Author), Ying Li (Author), Chunhui Yang (Author), Qi Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

IntroductionThis study aimed to investigate the role of Nicotinamide N-methyltransferase (NNMT) in the drug sensitivity of non-small cell lung cancer (NSCLC) cells, with a focus on its impact on autophagy and resistance to the chemotherapeutic agent osimertinib. The study hypothesized that NNMT knoc...