Effective chikungunya virus-like particle vaccine produced in insect cells.

• Main Authors: Stefan W Metz (Author), Joy Gardner (Author), Corinne Geertsema (Author), Thuy T Le (Author), Lucas Goh (Author), Just M Vlak (Author), Andreas Suhrbier (Author), Gorben P Pijlman (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The emerging arthritogenic, mosquito-borne chikungunya virus (CHIKV) causes severe disease in humans and represents a serious public health threat in countries where Aedes spp mosquitoes are present. This study describes for the first time the successful production of CHIKV virus-like particles (VLP...