Importance of TLR2 on hepatic immune and non-immune cells to attenuate the strong inflammatory liver response during Trypanosoma cruzi acute infection.

• Main Authors: Eugenio Antonio Carrera-Silva (Author), Natalia Guiñazu (Author), Andrea Pellegrini (Author), Roxana Carolina Cano (Author), Alfredo Arocena (Author), Maria Pilar Aoki (Author), Susana Gea (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: Toll-like receptors (TLR) and cytokines play a central role in the pathogen clearance as well as in pathological processes. Recently, we reported that TLR2, TLR4 and TLR9 are differentially modulated in injured livers from BALB/c and C57BL/6 (B6) mice during Trypanosoma cruzi infection....