miR-15a/-16 Inhibit Angiogenesis by Targeting the Tie2 Coding Sequence: Therapeutic Potential of a miR-15a/16 Decoy System in Limb Ischemia

• Автори: Marie Besnier (Автор), Saran Shantikumar (Автор), Maryam Anwar (Автор), Parul Dixit (Автор), Aranzazu Chamorro-Jorganes (Автор), Walid Sweaad (Автор), Graciela Sala-Newby (Автор), Paolo Madeddu (Автор), Anita C. Thomas (Автор), Lynsey Howard (Автор), Sobia Mushtaq (Автор), Enrico Petretto (Автор), Andrea Caporali (Автор), Costanza Emanueli (Автор)
• Формат: Книга
• Опубліковано: Elsevier, 2019-09-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

MicroRNA-15a (miR-15a) and miR-16, which are transcribed from the miR-15a/miR-16-1 cluster, inhibit post-ischemic angiogenesis. MicroRNA (miRNA) binding to mRNA coding sequences (CDSs) is a newly emerging mechanism of gene expression regulation. We aimed to (1) identify new mediators of the anti-ang...