miR-15a/-16 Inhibit Angiogenesis by Targeting the Tie2 Coding Sequence: Therapeutic Potential of a miR-15a/16 Decoy System in Limb Ischemia

• Main Authors: Marie Besnier (Author), Saran Shantikumar (Author), Maryam Anwar (Author), Parul Dixit (Author), Aranzazu Chamorro-Jorganes (Author), Walid Sweaad (Author), Graciela Sala-Newby (Author), Paolo Madeddu (Author), Anita C. Thomas (Author), Lynsey Howard (Author), Sobia Mushtaq (Author), Enrico Petretto (Author), Andrea Caporali (Author), Costanza Emanueli (Author)
• Format: Book
• Published: Elsevier, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

MicroRNA-15a (miR-15a) and miR-16, which are transcribed from the miR-15a/miR-16-1 cluster, inhibit post-ischemic angiogenesis. MicroRNA (miRNA) binding to mRNA coding sequences (CDSs) is a newly emerging mechanism of gene expression regulation. We aimed to (1) identify new mediators of the anti-ang...