Comparison of different methods to assess tacrolimus concentration intra-patient variability as potential marker of medication non-adherence

• Main Authors: Barbora Kostalova (Author), Katerina Mala-Ladova (Author), Sylvie Dusilova Sulkova (Author), Kris Denhaerynck (Author), Sabina De Geest (Author), Josef Maly (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background and objective: Non-adherence to tacrolimus commonly manifests as low drug concentrations and/or high intra-patient variability (IPV) of concentrations across multiple measurements. We aimed to compare several methods of tacrolimus IPV calculation and evaluate how well each reflects blood...