Genetic Ablation of Soluble TNF Does Not Affect Lesion Size and Functional Recovery after Moderate Spinal Cord Injury in Mice

• Main Authors: Ditte Gry Ellman (Author), Matilda Degn (Author), Minna Christiansen Lund (Author), Bettina Hjelm Clausen (Author), Hans Gram Novrup (Author), Simon Bertram Flæng (Author), Louise Helskov Jørgensen (Author), Lujitha Suntharalingam (Author), Åsa Fex Svenningsen (Author), Roberta Brambilla (Author), Kate Lykke Lambertsen (Author)
• Format: Book
• Published: Hindawi Limited, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Traumatic spinal cord injury (SCI) is followed by an instant increase in expression of the microglial-derived proinflammatory cytokine tumor necrosis factor (TNF) within the lesioned cord. TNF exists both as membrane-anchored TNF (mTNF) and as cleaved soluble TNF (solTNF). We previously demonstrated...