Systems Pharmacology Modeling Identifies a Novel Treatment Strategy for Bortezomib-Induced Neuropathic Pain

• Main Authors: Peter Bloomingdale (Author), Cristina Meregalli (Author), Kevin Pollard (Author), Annalisa Canta (Author), Alessia Chiorazzi (Author), Giulia Fumagalli (Author), Laura Monza (Author), Eleonora Pozzi (Author), Paola Alberti (Author), Elisa Ballarini (Author), Norberto Oggioni (Author), Louise Carlson (Author), Wensheng Liu (Author), Mehrnoosh Ghandili (Author), Tracey A. Ignatowski (Author), Kelvin P. Lee (Author), Michael J. Moore (Author), Guido Cavaletti (Author), Donald E. Mager (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chemotherapy-induced peripheral neurotoxicity is a common dose-limiting side effect of several cancer chemotherapeutic agents, and no effective therapies exist. Here we constructed a systems pharmacology model of intracellular signaling in peripheral neurons to identify novel drug targets for preven...