Lowest observed adverse effect level of pulmonary pathological alterations due to nitrous acid exposure in guinea pigs

• Main Authors: Masayuki Ohyama (Author), Hiroshi Nishimura (Author), Kenichi Azuma (Author), Chika Minejima (Author), Norimichi Takenaka (Author), Shuichi Adachi (Author)
• Format: Book
• Published: Komiyama Printing Co. Ltd, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background We previously demonstrated that continuous exposure to nitrous acid gas (HONO) for 4 weeks, at a concentration of 3.6 parts per million (ppm), induced pulmonary emphysema-like alterations in guinea pigs. In addition, we found that HONO affected asthma symptoms, based on the measu...