Physiologically-Based Pharmacokinetic Modelling to Predict the Pharmacokinetics and Pharmacodynamics of Linezolid in Adults and Children with Tuberculous Meningitis

• Main Authors: Carlijn H. C. Litjens (Author), Laurens F. M. Verscheijden (Author), Elin M. Svensson (Author), Petra H. H. van den Broek (Author), Hedwig van Hove (Author), Jan B. Koenderink (Author), Frans G. M. Russel (Author), Rob E. Aarnoutse (Author), Lindsey H. M. te Brake (Author)
• Format: Book
• Published: MDPI AG, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Linezolid is used off-label for treatment of central nervous system infections. However, its pharmacokinetics and target attainment in cranial cerebrospinal fluid (CSF) in tuberculous meningitis patients is unknown. This study aimed to predict linezolid cranial CSF concentrations and assess attainme...