Depletion of pyruvate kinase (PK) activity causes glycolytic intermediate imbalances and reveals a PK-TXNIP regulatory axis

• Main Authors: Anna Nieborak (Author), Saulius Lukauskas (Author), Jordi Capellades (Author), Patricia Heyn (Author), Gabriela Silva Santos (Author), Karsten Motzler (Author), Anja Zeigerer (Author), Romina Bester (Author), Ulrike Protzer (Author), Florian Schelter (Author), Mirko Wagner (Author), Thomas Carell (Author), Alexander Hruscha (Author), Bettina Schmid (Author), Oscar Yanes (Author), Robert Schneider (Author)
• Format: Book
• Published: Elsevier, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Cancer cells convert more glucose into lactate than healthy cells, what contributes to their growth advantage. Pyruvate kinase (PK) is a key rate limiting enzyme in this process, what makes it a promising potential therapeutic target. However, currently it is still unclear what consequenc...