Perinatal Management of Bart's Hemoglobinopathy: Paradoxical Effects of Intrauterine, Transplacental, and Partial Exchange Transfusions

• Main Authors: Mark Curran (Author), Michel Mikhael (Author), Wang-Dar Sun (Author), Jina Lim (Author), Anna Leung (Author), Gira Morchi (Author), Ramen H. Chmait (Author)
• Format: Book
• Published: Thieme Medical Publishers, Inc., 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We describe a fetus at 24 3/7 weeks' gestation that showed ultrasound evidence of anemia, hydrops, and severe growth restriction. Both parents were known to be cis heterozygous carriers for SEA α-thalassemia deletion (αα/-). Cordocentesis confirmed fetal anemia and homozygous α-thalassemia (−/−...