Celastrol induces ferroptosis in activated HSCs to ameliorate hepatic fibrosis via targeting peroxiredoxins and HO-1

• Main Authors: Piao Luo (Author), Dandan Liu (Author), Qian Zhang (Author), Fan Yang (Author), Yin-Kwan Wong (Author), Fei Xia (Author), Junzhe Zhang (Author), Jiayun Chen (Author), Ya Tian (Author), Chuanbin Yang (Author), Lingyun Dai (Author), Han-Ming Shen (Author), Jigang Wang (Author)
• Format: Book
• Published: Elsevier, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ferroptosis is a form of regulated cell death, characterized by excessive membrane lipid peroxidation in an iron- and ROS-dependent manner. Celastrol, a natural bioactive triterpenoid extracted from Tripterygium wilfordii, shows effective anti-fibrotic and anti-inflammatory activities in multiple he...