BioPhi: A platform for antibody design, humanization, and humanness evaluation based on natural antibody repertoires and deep learning

• Main Authors: David Prihoda (Author), Jad Maamary (Author), Andrew Waight (Author), Veronica Juan (Author), Laurence Fayadat-Dilman (Author), Daniel Svozil (Author), Danny A. Bitton (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Despite recent advances in transgenic animal models and display technologies, humanization of mouse sequences remains one of the main routes for therapeutic antibody development. Traditionally, humanization is manual, laborious, and requires expert knowledge. Although automation efforts are advancin...