PBPK-PD modeling for the preclinical development and clinical translation of tau antibodies for Alzheimer's disease

• Main Authors: Peter Bloomingdale (Author), Daniela Bumbaca-Yadav (Author), Jonathan Sugam (Author), Steve Grauer (Author), Brad Smith (Author), Svetlana Antonenko (Author), Michael Judo (Author), Glareh Azadi (Author), Ka Lai Yee (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Disrupted tau proteostasis and transneuronal spread is a pathological hallmark of Alzheimer's disease. Neurodegenerative diseases remain an unmet medical need and novel disease modifying therapeutics are paramount. Our objective was to develop a mechanistic mathematical model to enhance our und...