Zebrafish neurofibromatosis type 1 genes have redundant functions in tumorigenesis and embryonic development

• Main Authors: Jimann Shin (Author), Arun Padmanabhan (Author), Eric D. de Groh (Author), Jeong-Soo Lee (Author), Sam Haidar (Author), Suzanne Dahlberg (Author), Feng Guo (Author), Shuning He (Author), Marc A. Wolman (Author), Michael Granato (Author), Nathan D. Lawson (Author), Scot A. Wolfe (Author), Seok-Hyung Kim (Author), Lilianna Solnica-Krezel (Author), John P. Kanki (Author), Keith L. Ligon (Author), Jonathan A. Epstein (Author), A. Thomas Look (Author)
• Format: Book
• Published: The Company of Biologists, 2012-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY Neurofibromatosis type 1 (NF1) is a common, dominantly inherited genetic disorder that results from mutations in the neurofibromin 1 (NF1) gene. Affected individuals demonstrate abnormalities in neural-crest-derived tissues that include hyperpigmented skin lesions and benign peripheral nerve...