Involvement of Intracellular Ca2+ in the Regulatory Volume Decrease After Hyposmotic Swelling in MDCK Cells

• Main Authors: Naoko Iida-Tanaka (Author), Iyuki Namekata (Author), Megumi Kaneko (Author), Miku Tamura (Author), Toru Kawanishi (Author), Ryu Nakamura (Author), Koki Shigenobu (Author), Hikaru Tanaka (Author)
• Format: Book
• Published: Elsevier, 2007-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We examined the source of Ca2+ involved in the volume regulation of Madin-Darby canine kidney (MDCK) cells with confocal microscopy and fluoroprobes. Hyposmosis induced a transient increase in cell volume, as well as cytoplasmic Ca2+, which peaked at 3 to 5 min and gradually decreased to reach the i...