A novel anti-NGF PEGylated Fab' provides analgesia with lower risk of adverse effects

• Main Authors: Yukari Koya (Author), Hirotsugu Tanaka (Author), Eiji Yoshimi (Author), Nobuaki Takeshita (Author), Shuji Morita (Author), Hiroki Morio (Author), Kanako Mori (Author), Hiroshi Fushiki (Author), Masazumi Kamohara (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTNerve growth factor (NGF) has emerged as a key driver of pain perception in several chronic pain conditions, including osteoarthritis (OA), and plays an important role in the generation and survival of neurons. Although anti-NGF antibodies improve pain control and physical function in patien...