An innovative ethosuximide granule formulation designed for pediatric use: Comparative pharmacokinetics, safety, tolerability, and palatability profile versus reference syrup

• Главные авторы: Léonore Diezi (Автор), Kim Dao (Автор), Vincent Jullien (Автор), Caroline Roussel‐Maupetit (Автор), Ingrid Burton (Автор), Pascal André (Автор), Carine Bardinet (Автор), Laura E. Rothuizen (Автор), Haithem Chtioui (Автор), Maria A. Manso‐Silvan (Автор), Catherine Guittet (Автор), Françoise Brunner‐Ferber (Автор), Francois Vandenhende (Автор), Catherine Chiron (Автор), Luc‐André Granier (Автор), Thierry Buclin (Автор)
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• Опубликовано: Wiley, 2023-02-01T00:00:00Z.
• Предметы: article
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Abstract Ethosuximide, the first‐line therapy for childhood absence epilepsy, is currently formulated as a syrup (Zarontin®, Pfizer) with a bitter taste and high sugar content, poorly adapted to children, and a ketogenic diet. The collaborative European FP7 project KIEKIDS aimed at developing an inn...