Pharmacokinetics of Haloperidol in Critically Ill Patients: Is There an Association with Inflammation?

• Main Authors: Letao Li (Author), Sebastiaan D. T. Sassen (Author), Mathieu van der Jagt (Author), Henrik Endeman (Author), Birgit C. P. Koch (Author), Nicole G. M. Hunfeld (Author)
• Format: Book
• Published: MDPI AG, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Haloperidol is considered the first-line treatment for delirium in critically ill patients. However, clinical evidence of efficacy is lacking and no pharmacokinetic studies have been performed in intensive care unit (ICU) patients. The aim of this study was to establish a pharmacokinetic model to de...