Glypican-3 gene silencing for ovarian cancer using siRNA-PLGA hybrid micelles in a murine peritoneal dissemination model

• Main Authors: Mai Hazekawa (Author), Takuya Nishinakagawa (Author), Tomoyo Kawakubo-Yasukochi (Author), Manabu Nakashima (Author)
• Formato: Livro
• Publicado em: Elsevier, 2019-03-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Small interfering RNA (siRNA) has received much attention and for possible therapeutic applications to treat incurable chronic and genetic diseases, including cancer. However, the development of safe and efficient carriers for siRNA delivery still remains formidable hurdles for in vivo. The purpose...