HLA-E: Presentation of a Broader Peptide Repertoire Impacts the Cellular Immune Response-Implications on HSCT Outcome

• Autores principales: Thomas Kraemer (Autor), Alexander A. Celik (Autor), Trevor Huyton (Autor), Heike Kunze-Schumacher (Autor), Rainer Blasczyk (Autor), Christina Bade-Döding (Autor)
• Formato: Libro
• Publicado: Hindawi Limited, 2015-01-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

The HLA-E locus encodes a nonclassical class Ib molecule that serves many immune functions from inhibiting NK cells to activating CTLs. Structural analysis of HLA-E/NKG2A complexes visualized fine-tuning of protective immune responses through AA interactions between HLA-E, the bound peptide, and NKG...