Targeting RGMb interactions: Discovery and preclinical characterization of potent anti-RGMb antibodies blocking multiple ligand bindings

• Main Authors: Maria Meira (Author), Aurore Frey (Author), Neila Chekkat (Author), Magda Rybczynska (Author), Zaki Sellam (Author), Joon Seok Park (Author), Francesca Smylie Gazzaniga (Author), Alexia Parmentier (Author), Marianne Le Gall (Author), Gordon James Freeman (Author), Dennis Lee Kasper (Author), Arlene Helen Sharpe (Author), Eric Rambeaux (Author), Abdijapar Shamshiev (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Therapeutic efficacy with durable responses has been demonstrated with several antibody drugs that block key immune checkpoint receptors, including PD-1, PD-L1, and CTLA-4. Despite the success of these drugs, a substantial proportion of patients do not benefit. Targeting multiple inhibitory pathways...