Small changes in the length of diselenide bond-containing linkages exert great influences on the antitumor activity of docetaxel homodimeric prodrug nanoassemblies

• Main Authors: Lingxiao Li (Author), Shiyi Zuo (Author), Fudan Dong (Author), Tian Liu (Author), Yanlin Gao (Author), Yinxian Yang (Author), Xin Wang (Author), Jin Sun (Author), Bingjun Sun (Author), Zhonggui He (Author)
• Format: Book
• Published: Elsevier, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Homodimeric prodrug-based self-assembled nanoparticles, with carrier-free structure and ultrahigh drug loading, is drawing more and more attentions. Homodimeric prodrugs are composed of two drug molecules and a pivotal linkage. The influence of the linkages on the self-assembly, in vivo fate and ant...