In Vivo Delivery of miR-34a Sensitizes Lung Tumors to Radiation Through RAD51 Regulation

• Main Authors: Maria Angelica Cortez (Author), David Valdecanas (Author), Sharareh Niknam (Author), Heidi J Peltier (Author), Lixia Diao (Author), Uma Giri (Author), Ritsuko Komaki (Author), George A Calin (Author), Daniel R Gomez (Author), Joe Y Chang (Author), John Victor Heymach (Author), Andreas G Bader (Author), James William Welsh (Author)
• Format: Book
• Published: Elsevier, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

MiR-34a, an important tumor-suppressing microRNA, is downregulated in several types of cancer; loss of its expression has been linked with unfavorable clinical outcomes in non-small-cell lung cancer (NSCLC), among others. MiR-34a represses several key oncogenic proteins, and a synthetic mimic of miR...