FX11 limits Mycobacterium tuberculosis growth and potentiates bactericidal activity of isoniazid through host-directed activity

• Main Authors: Gopinath Krishnamoorthy (Author), Peggy Kaiser (Author), Ulrike Abu Abed (Author), January Weiner (Author), Pedro Moura-Alves (Author), Volker Brinkmann (Author), Stefan H. E. Kaufmann (Author)
• Format: Book
• Published: The Company of Biologists, 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lactate dehydrogenase A (LDHA) mediates interconversion of pyruvate and lactate, and increased lactate turnover is exhibited by malignant and infected immune cells. Hypoxic lung granuloma in Mycobacterium tuberculosis-infected animals present elevated levels of Ldha and lactate. Such alterations in...