Natural terpenoids from Ambrosia species are active in vitro and in vivo against human pathogenic trypanosomatids.

• Main Authors: Valeria P Sülsen (Author), Silvia I Cazorla (Author), Fernanda M Frank (Author), Laura C Laurella (Author), Liliana V Muschietti (Author), Cesar A Catalán (Author), Virginia S Martino (Author), Emilio L Malchiodi (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Among the natural compounds, terpenoids play an important role in the drug discovery process for tropical diseases. The aim of the present work was to isolate antiprotozoal compounds from Ambrosia elatior and A. scabra. The sesquiterpene lactone (STL) cumanin was isolated from A. elatior whereas two...