Increased complement activation 3 to 6 h after trauma is a predictor of prolonged mechanical ventilation and multiple organ dysfunction syndrome: a prospective observational study

• Main Authors: Ingrid Nygren Rognes (Author), Søren Erik Pischke (Author), William Ottestad (Author), Jo Røislien (Author), Jens Petter Berg (Author), Christina Johnson (Author), Torsten Eken (Author), Tom Eirik Mollnes (Author)
• Format: Book
• Published: BMC, 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Complement activation is a central mechanism in systemic inflammation and remote organ dysfunction following major trauma. Data on temporal changes of complement activation early after injury is largely missing. We aimed to describe in detail the kinetics of complement activation...