Ascl1 phospho-status regulates neuronal differentiation in a Xenopus developmental model of neuroblastoma

• Main Authors: Luke A. Wylie (Author), Laura J. A. Hardwick (Author), Tatiana D. Papkovskaia (Author), Carol J. Thiele (Author), Anna Philpott (Author)
• Format: Book
• Published: The Company of Biologists, 2015-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Neuroblastoma (NB), although rare, accounts for 15% of all paediatric cancer mortality. Unusual among cancers, NBs lack a consistent set of gene mutations and, excluding large-scale chromosomal rearrangements, the genome seems to be largely intact. Indeed, many interesting features of NB suggest tha...