The therapeutic potential of PX-478 in a murine model of pelvic organ prolapse

• Main Authors: Wei-Min Fan (Author), Yu-Qi Yang (Author), Li-Wen Zhang (Author), Xiao-Hui Mei (Author), Ke Sun (Author), Duan-Qing Wu (Author), Ying Yang (Author), Chun-Fang Duan (Author), Jun Ye (Author), Ru-Jun Chen (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background Pelvic organ prolapse (POP), characterised by the downward displacement of pelvic organs, is a prevalent disorder that affects adult women. This study explored the therapeutic potential of PX-478, a selective hypoxia-inducible factor-1α (HIF-1α) inhibitor, in a murine POP model.Methods A...