Impaired aerobic capacity and premature fatigue preceding muscle weakness in the skeletal muscle Tfam-knockout mouse model

• Main Authors: Benjamin Chatel (Author), Sylvie Ducreux (Author), Zeina Harhous (Author), Nadia Bendridi (Author), Isabelle Varlet (Author), Augustin C. Ogier (Author), Monique Bernard (Author), Julien Gondin (Author), Jennifer Rieusset (Author), Håkan Westerblad (Author), David Bendahan (Author), Charlotte Gineste (Author)
• Format: Book
• Published: The Company of Biologists, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mitochondrial diseases are genetic disorders that lead to impaired mitochondrial function, resulting in exercise intolerance and muscle weakness. In patients, muscle fatigue due to defects in mitochondrial oxidative capacities commonly precedes muscle weakness. In mice, deletion of the fast-twitch s...