Longitudinal study of leukocyte DNA methylation and biomarkers for cancer risk in older adults

• Main Authors: Alexandra H. Bartlett (Author), Jane W. Liang (Author), Jose Vladimir Sandoval-Sierra (Author), Jay H. Fowke (Author), Eleanor M. Simonsick (Author), Karen C. Johnson (Author), Khyobeni Mozhui (Author)
• Format: Book
• Published: BMC, 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Changes in DNA methylation over the course of life may provide an indicator of risk for cancer. We explored longitudinal changes in CpG methylation from blood leukocytes, and likelihood of future cancer diagnosis. Methods Peripheral blood samples were obtained at baseline and at...