Context matters - Daxx and Atrx are not robust tumor suppressors in the murine endocrine pancreas

• Main Authors: Chang Sun (Author), Jeannelyn S. Estrella (Author), Elizabeth M. Whitley (Author), Gilda P. Chau (Author), Guillermina Lozano (Author), Amanda R. Wasylishen (Author)
• Formato: Livro
• Publicado em: The Company of Biologists, 2022-08-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Genome sequencing has revealed the importance of epigenetic regulators in tumorigenesis. The genes encoding the chromatin remodeling complex DAXX:ATRX are frequently mutated in pancreatic neuroendocrine tumors; however, the underlying mechanisms of how mutations contribute to tumorigenesis are only...