Context matters - Daxx and Atrx are not robust tumor suppressors in the murine endocrine pancreas

• Asıl Yazarlar: Chang Sun (Yazar), Jeannelyn S. Estrella (Yazar), Elizabeth M. Whitley (Yazar), Gilda P. Chau (Yazar), Guillermina Lozano (Yazar), Amanda R. Wasylishen (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: The Company of Biologists, 2022-08-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Genome sequencing has revealed the importance of epigenetic regulators in tumorigenesis. The genes encoding the chromatin remodeling complex DAXX:ATRX are frequently mutated in pancreatic neuroendocrine tumors; however, the underlying mechanisms of how mutations contribute to tumorigenesis are only...