Mechanistic Modelling Identifies and Addresses the Risks of Empiric Concentration-Guided Sorafenib Dosing

The primary objective of this study is to evaluate the capacity of concentration-guided sorafenib dosing protocols to increase the proportion of patients that achieve a sorafenib maximal concentration (C<sub>max</sub>) within the range 4.78 to 5.78 μg/mL. A full physiologically based pha...

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Main Authors: Warit Ruanglertboon (Author), Michael J. Sorich (Author), Ashley M. Hopkins (Author), Andrew Rowland (Author)
Formato: Libro
Publicado: MDPI AG, 2021-04-01T00:00:00Z.
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