Identification of a pharmacological approach to reduce ACE2 expression and development of an in vitro COVID-19 viral entry model

• Main Authors: Yukinori Endo (Author), Brady T. Hickerson (Author), Natalia A. Ilyushina (Author), Nishant Mohan (Author), Hanjing Peng (Author), Kazuyo Takeda (Author), Raymond P. Donnelly (Author), Wen Jin Wu (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Because of rapid emergence and circulation of the SARS-CoV-2 variants, especially Omicron which shows increased transmissibility and resistant to antibodies, there is an urgent need to develop novel therapeutic drugs to treat COVID-19. In this study we developed an in vitro cellular model to explore...