Binding and Signaling Studies Disclose a Potential Allosteric Site for Cannabidiol in Cannabinoid CB2 Receptors

• Main Authors: Eva Martínez-Pinilla (Author), Katia Varani (Author), Irene Reyes-Resina (Author), Edgar Angelats (Author), Fabrizio Vincenzi (Author), Carlos Ferreiro-Vera (Author), Julen Oyarzabal (Author), Enric I. Canela (Author), José L. Lanciego (Author), Xavier Nadal (Author), Gemma Navarro (Author), Pier Andrea Borea (Author), Rafael Franco (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The mechanism of action of cannabidiol (CBD), the main non-psychotropic component of Cannabis sativa L., is not completely understood. First assumed that the compound was acting via cannabinoid CB2 receptors (CB2Rs) it is now suggested that it interacts with non-cannabinoid G-protein-coupled recepto...