Differences in bioavailability and cognitive-enhancing activity exerted by different crystal polymorphs of latrepirdine (Dimebon®)

• Main Authors: Boris I. Gorin (Author), Elena A. Tukhovskaya (Author), Alina M. Ismailova (Author), Gulsara A. Slashcheva (Author), Oksana A. Lenina (Author), Konstantin A. Petrov (Author), Ilya V. Kazeev (Author), Arkady N. Murashev (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Pharmacokinetic characteristics as well as cognitive-enhancing nootropic activity of latrepirdine (Dimebon®) in relationship with its polymorphic forms have been studied in SD and Wistar rats.Methods: The pharmacokinetics of six polymorphs (A, B, C, D, E, F) of latrepirdine were studie...